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KMID : 1009020090070010003
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Clinical Psychopharmacology and Neuroscience
2009 Volume.7 No. 1 p.3 ~ p.8
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Mild Cognitive Impairment (MCI): Pathogenesis and Treatments
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Ha Il-Ho
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Abstract
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Mild cognitive impairment (MCI), poorly defined for many years, has recently been described as a transition state from healthy cognitive ageing into dementia. This intrinsic heterogeneity renders exact assessments of prevalence, prognosis, and treatment problematic. Understanding the etiology of MCI might provide useful knowledge for the prevention of Alzheimer’s disease (AD) because patients with MCI are closer to AD than are those without MCI. Clinical trials with existing compounds have failed to find any positive effects on MCI treatment. To overcome current failures in MCI therapeutics, future research should focus on better understanding the etiology of this condition and developing new compounds based on such knowledge.
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KEYWORD
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Mild cognitive impairment (MCI), Oxidation, Inflammation, Neuroprotection, Alzheimer’s disease, Animal model
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